|
Acute Promyelocytic Leukemia
|
0.600 |
Biomarker
|
disease |
CTD_human |
[Therapeutic results with apl 93 protocol in acute promyelocytic leukemia (34 cases)].
|
17294898 |
2006 |
|
Acute Promyelocytic Leukemia
|
0.600 |
Biomarker
|
disease |
CTD_human |
[Can As2O3 improve the prognosis of childhood acute promyelocytic leukemia?--A single center experience].
|
19035177 |
2008 |
|
Acute Promyelocytic Leukemia
|
0.600 |
Biomarker
|
disease |
CTD_human |
[Application of all-trans retinoic acid combining chemotherapy and As4S4 in the maintenance treatment of patients with acute promyelocytic leukemia].
|
17649720 |
2007 |
|
Acute Promyelocytic Leukemia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
While most cases of APL harboring the PML/RARA fusion respond to all-trans retinoic acid (ATRA), some variant RARA rearrangements are ATRA insensitive.
|
31447065 |
2019 |
|
Acute Promyelocytic Leukemia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Whereas the retinoic acid receptor beta (RARbeta) rearrangement in hepatocellular carcinoma is unique, in acute promyelocytic leukemia (APL), RARalpha fusion to the promyelocytic leukemia (PML) gene by the t(15;17) translocation is a general feature of the disease.
|
8801177 |
1996 |
|
Acute Promyelocytic Leukemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
We utilized a murine model of APL in which the PML-RARalpha oncogene is expressed from the endogenous cathepsin G promoter to test the hypothesis that leukemia stem cell (LSC) activity resides within the differentiated promyelocyte compartment.
|
19322209 |
2009 |
|
Acute Promyelocytic Leukemia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We used RARA FISH at the initial diagnosis (16 cases) and follow-up of APL patients (21 cases) with t(15;17), though RARA FISH was originally designed to detect translocations involving the RARA gene rather than t(15;17), and compared the results with those of PML/RARA FISH.
|
12550769 |
2002 |
|
Acute Promyelocytic Leukemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
We took advantage of a recently developed system allowing performance of real-time quantitation of polymerase chain reaction to develop a quantitative method of measurement of PML-RARalpha transcripts which are hallmarks of acute promyelocytic leukemia (APL) with t(15;17) translocation.
|
10673752 |
2000 |
|
Acute Promyelocytic Leukemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
We suggest that alternative splicing of PML/RARalpha transcripts might be involved in NMD and each isoform should be quantified to further understand the pathogenesis of APL, stratify the risk of relapse, and monitor minimal residual disease.
|
19863682 |
2010 |
|
Acute Promyelocytic Leukemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
We studied 203 patients with PML-RARA-positive APL; 43% of the patients had an FLT3 mutation (65 internal tandem duplications [ITDs], 19 D835/I836, 4 ITD+D835/I836).
|
16105978 |
2005 |
|
Acute Promyelocytic Leukemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
We show that the viral EBNA1 protein, previously known to be required to maintain the EBV episomes, also causes the disruption of the cellular PML (promyelocytic leukemia) nuclear bodies (or ND10s).
|
18833293 |
2008 |
|
Acute Promyelocytic Leukemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
We show that in APL, As2O3 leads to the rapid reformation of PML bodies.
|
8986606 |
1996 |
|
Acute Promyelocytic Leukemia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We report on an APL patient with iso(17q) as the sole cytogenetic aberration and a cryptic PML-RARA transcript, who was treated with ATRA and ATO after failure of chemotherapy and achieved complete remission.
|
26471811 |
2015 |
|
Acute Promyelocytic Leukemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
We report here the regulatory mechanism of the repression of PU.1-dependent activation of PSMBs by PML/RARα in the pathogenesis of acute promyelocytic leukemia (APL) and the unidentified function of all-trans retinoic acid (ATRA) as an immunomodulator in the treatment of APL.
|
23770850 |
2014 |
|
Acute Promyelocytic Leukemia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We report here that the fusion of PML, a nuclear protein defined by the t(15;17) chromosomal translocation in acute promyelocytic leukemia, with retinoic acid receptor alpha (RAR alpha) changes the RAR alpha from a retinoic acid (RA)-dependent inhibitor to a RA-dependent activator of AP-1 transcriptional activity.
|
8415704 |
1993 |
|
Acute Promyelocytic Leukemia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We report here that PML is expressed at low levels or not expressed in normal circulating human monocytes, lymphocytes, and polymorphonucleate cells, but is markedly induced by interferon; that PML and PML/RAR alpha expression is augmented by interferon in the NB4 APL cell line, which carries the t(15; 17), and in APL blasts from patients; that interferon inhibits growth and survival of NB4 APL cells in cooperation with RA; that interferons alone have minimal maturation effect on NB4 cells; and, finally, that interferon gamma, but not alpha or beta, induces maturation and growth suppression of NB4 cells with de novo retinoid resistance, and partially restores RA response.
|
8916959 |
1996 |
|
Acute Promyelocytic Leukemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
We report here an APL clone with a cryptic PML-RARA fusion that returned negative results by both karyotyping and fluorescence in situ hybridization (FISH), but returned positive results by RT-PCR analysis.
|
22982005 |
2012 |
|
Acute Promyelocytic Leukemia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We report APL cases with submicroscopic 15;17 recombinations leading to the formation of nonreciprocal PML/RARa or RARa/PML fusion genes.
|
7858248 |
1995 |
|
Acute Promyelocytic Leukemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
We propose the oncoprotein-dependent PML-NB disruption and DDR impairment as relevant early events in APL tumorigenesis.
|
27468685 |
2016 |
|
Acute Promyelocytic Leukemia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We know of no previous reports of APL during pregnancy associated with variant PML/RARA fusion transcripts.
|
19061780 |
2009 |
|
Acute Promyelocytic Leukemia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated the organization and expression pattern of the RAR alpha-PML gene in a series of APL patients representative of the molecular heterogeneity of the t(15;17) and found (i) two types of RAR alpha-PML mRNA junctions (RAR alpha exon 2/PML exon 4 or RAR alpha exon 2/PML exon 7) that maintain the RAR alpha and PML longest open reading frames aligned and are the result of chromosome 15 breaking at two different sites; and (ii) 10 different RAR alpha-PML fusion transcripts that differ for the assembly of their PML coding exons.
|
1317574 |
1992 |
|
Acute Promyelocytic Leukemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
We investigated the activity of As2O3 and melarsoprol in a broader context encompassing various myeloid leukemia cell lines, including the APL cell line NB4-306 (a retinoic acid-resistant cell line derived from NB4 that no longer expresses the intact PML-RARalpha fusion protein), HL60, KG-1, and the myelomonocytic cell line U937.
|
9716575 |
1998 |
|
Acute Promyelocytic Leukemia
|
0.600 |
Biomarker
|
disease |
CTD_human |
We identified one ATO-resistant t-APL patient, who presented a PML A216T mutation in both the rearranged and unrearranged PML alleles, and two mutations in the rearranged RARA gene.
|
26728337 |
2016 |
|
Acute Promyelocytic Leukemia
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
We identified DNA sequence variations resulting in a truncated PML protein in APL cases that displayed RA resistance and a very poor prognosis.
|
14630830 |
2004 |
|
Acute Promyelocytic Leukemia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We hypothesized that PML/RARA-mediated downregulation of <i>Irf8</i> transcript levels contributes to the initiation of APL.
|
30266821 |
2018 |